Roma coach Rudi Garcia says defender Leandro Castan and midfielder Kevin Strootman will soon be back in action for the club.
The two have been ruled out for months with the defender also missing most of last season due to requiring brain surgery.
Striker Edin Dzeko has been training with the rest of the squad and is expected to face Empoli on Saturday.
"I have to say that Bosnia managed him [Edin Dzeko] very well," Garcia told reporters.
"He wasn't ready to play and he didn't. He might have come on during the second game, but in the end he didn't. Today he trained with the group for the whole session. He's rediscovering his fitness and starting to play without fear again.
"It's possible [Castan will return]. The absence of Seydou Keita in midfield means we can't play seven matches with Daniele De Rossi in central defense, even though he's done well there.
"We need to get Castan and Toni Rudiger back, not just tomorrow but for all of our upcoming matches. For both of them it's just a case of rediscovering their match sharpness.
"I hope Kevin [Strootman] can return soon. I've never seen him looking so relaxed and happy, not even after his first injury. This is his third lay-off for the same knee, so he needs time.
"We're respecting the recovery timescales but we're confident and can't wait to have him back at 100%. As for Leo Castan, I have a special relationship with him.
"He's almost like a son to me. I'll be delighted when he's back at full fitness and he'll get there soon.
"All he's lacking is match fitness and that's because he's been out for a year. He's looking good and is very enthusiastic. I'm always honest with him. He's a very important player for our future."