Manchester United manager Louis van Gaal says his side can still finish in the Top Four.
The Red Devils could only manage a draw at home against Leicester City as they failed to close the gap on third-placed Manchester City.
But the Dutchman says Southampton can beat the Citizens and keep the Top Four race alive for his team.
"I think we played one of our best matches of the season, but it was not enough," van Gaal said.
"It was a very difficult match for the referee - when you see what Huth is doing with Fellaini, is that not a penalty?
"Every human being who is grabbed with their hair would react. It is tougher when you don't win, of course it is tougher [to finish in the top four].
"But Manchester City have to play Southampton away, so we are still in the race. For me Tottenham can also win - the best has to win.
"Tottenham has more points against us, but I think Leicester City deserves to win this championship. They have very good organisation, but we have a lot of chances.
"It could have [been a red card for Danny Simpson] because he was Danny Simpson and he was the last man, but it was not a heavy foul so I can understand why he didn't give it."