Manchester United boss Louis van Gaal says Phil Jones, Antonio Valencia and Marouane Fellaini could all start Sunday's game against West Bromwich Albion.
The trio missed the mid-week win against Watford at Old Trafford but are expected to be fit to be in the squad to face Tony Pulis' men.
Striker Wayne Rooney is still on the sidelines with winger Ashley Young expected to make his long-awaited comeback from injury at the end of the month.
"Players are coming back but then, normally, they cannot play a match because the rhythm of the game is much higher," van Gaal told MUTV.
"So, we have to train more and let them play in the second team. Maybe because I'm forced because of the circumstances to take a risk, like I have done with Marcos Rojo but, when I'm not forced to, then I shall not do that.
"A lot [of players] can do that [make Sunday's squad] but it's also what I have already told - I don't want to take a risk.
"[Antonio] Valencia is coming back, [Marouane] Fellaini is coming back, [Phil] Jones is coming back. A lot of players are coming back, and I have said that in former press conferences.
"Will [Keane] had a fantastic operation, like Ashley Young.
"It was more or less the same operation. He is coming back on Tuesday and I'm hoping he comes back as quickly as Ashley because he's also coming back in March. Schweinsteiger may train with the first team next week."