Manchester United manager Louis van Gaal admits the high number of injuries in his side is a concern.
The Red Devils are today away at Sunderland with Phil Jones, Guillermo Varela and Adnan Januzaj all suffering injuries during the Under 21's 7-0 win over Norwich City.
They join Bastian Schweinsteiger, Luke Shaw, Marcos Rojo and Antonio Valencia on the sidelines.
"It's not looking good because I also let my players play in the second team and various players were injured again," van Gaal told MUTV.
"They're not very nasty injuries but I still have to give them time to recover.
"It is a big pity because Jones is a very good central defender and we are missing him and also Marcos Rojo for a long time already.
"I cannot say Bastian [Schweinsteiger] is returning within two weeks because I have given him, more or less, a little holiday as he also has to change his mindset.
"It's good for players. I have done that also with Antonio Valencia, Marcos Rojo and Luke Shaw, for example, when you are injured for longer than normal.
"The light at the end of the tunnel is more for Rojo and for Valencia. They are coming back and I hope it's as soon as possible."