Manchester United boss Louis van Gaal has confirmed that a number of key players will not feature against CSKA Moscow on Wednesday evening.
The Red Devils registered a much-needed win against Wolfsburg in their last game in the competition and will be determined to produce more of the same against the Russians at the Arena Khimki.
"It's the same amount of injuries," van Gaal told MUTV.
"Luke Shaw, Paddy McNair and Ashley Young are not going with us. Willo was a little bit ill – Wilson as he is named but, for us, it is Willo – so he shall not travel with us.
"I'll take 20 players with me. It's a four-hour flight so, if a player gets ill, I have the other player in my environment.
"Of course that was the reason [Romero and Valencia were absent at Everton]. They have to cope with the jet-lag so I didn't think it was wise to take them with us against Everton."