Manchester United boss Louis van Gaal has admitted that the injury suffered by left-back Luke Shaw has left an important void in the team's defensive department.
The 20-year-old defender had surgery in mid-week after suffering a double fracture of his right leg during the Red Devils' 2-1 Champions League defeat against PSV Eindhoven.
And the Dutchman confirmed that Daley Blind, Marcos Rojo - who took over from the Englishman in Holland - and Ashley Young could all cover for the youngster.
"It's a great loss," van Gaal admitted.
"I have said in advance of this season already that it shall be the season of Luke Shaw. He had started fantastically and everybody had seen that. It is a great miss, a great loss.
"You have to build up again a combination with the player in front of him. Memphis and Shaw were a very good combination and now you have to build up a new combination. You have to start again and that is difficult.
"It's also difficult for the player who has to replace him [because] he is very difficult to replace, certainly when he is in such good shape.
"But we have good replacements in [Daley] Blind, [Marcos] Rojo and in Ashley Young."