Manchester United boss Louis van Gaal has revealed that defender Luke Shaw and striker Wayne Rooney will boss miss Sunday's home game against Arsenal.
The Red Devils are almost certain to finish in the top four this season and have a small chance of overtaking the Gunners in the table.
"The situation is not positive for us, they [Luke Shaw and Wayne Rooney] cannot play, neither of them," van Gaal told MUTV.
"It is a short-term thing, we have only one match to play [after Arsenal], so I think it will be difficult for them to play again this season.
"Angel Di Maria and Robin van Persie are able to play. Rojo has trained this week with us and he could play."
Meanwhile, the Dutchman says a top four finish is exactly what he wanted to achieve in his first year in charge.
"We sat together, myself and the board, and set the goal, which was to finish in the first four," he explained.
"And we have reached that two games before the end of the season, which is not bad I think.
"I am satisfied about the second part of the season but in the first part of the season we had an average of 10 injuries a week. We never lined up the same but I'm happy now."