Manchester United boss Louis van Gaal reveals a number of key players will not feature against Chelsea.
Midfielder Michael Carrick joins Daley Blind, Phil Jones and Marcos Rojo on the sidelines but striker Robin van Persie could be in the squad to face Jose Mourinho's men on Saturday.
"Carrick is injured, he cannot play," van Gaal told MUTV.
"But not only Michael Carrick - Daley Blind, Phil Jones and Marcos Rojo cannot play. It cannot be worse because it's two players in the left central defensive positions, and Jonny Evans is still suspended.
"Blind and Carrick play in the holding position in midfield, so I have to change my line-up a lot against Chelsea.
"They [the injuries] are all from the game against Manchester City. Blind has played on because he always wants to play on, but the tackle from [Vincent] Kompany was of course the reason.
"Jones, I took him off the pitch already because he injured himself in the second half. Rojo, he was complaining after the match, and Carrick was also off.
"It's not surprising, but we had a big hope that Blind and Jones could reach this game but they could not.
"Shaw has trained for a lot of weeks already so he can play. Van Persie is another story. This is the first week he's trained with the first team, but maybe we have to think about him."