Manchester United manager Louis van Gaal says a number of youth players will feature against West Ham United on Saturday.
The Red Devils will be desperate to get all three points against Sam Allardyce's men but the Dutchman will have to resort to creativity to pick the players to start in the defensive department.
"[Chris] Smalling came out of yesterday's training session because he had stiff legs," van Gaal told reporters during Thursday's press conference.
"I won't take risks with players - they have to be fit.
"Jonny Evans' bone is bruised a lot and we have to wait and see how it goes. I have nine injuries now and one player suspended with Blackett.
"All three of my right-sided centre-halves are out, so I will have to go to the youth education [system] and pick players from there.
"The young players are always ready [to start]. They are hungry to play the game.
"United's youth education has a level that can provide that. There's a big difference between youth games and the Premier League but in one game you can show [prove] yourself."